Abraham Lab at
Queen's University

Abraham Lab at Queen's UniversityAbraham Lab at Queen's UniversityAbraham Lab at Queen's University

Abraham Lab at
Queen's University

Abraham Lab at Queen's UniversityAbraham Lab at Queen's UniversityAbraham Lab at Queen's University
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Select Publications

  1.  Grenier-Pleau I, Abraham S. Extracellular vesicles tell all: How vesicle-mediated cellular communication shapes hematopoietic stem cell biology with increasing age. Exp Hematol. 2021 Aug 15:S0301-472X(21)00284-8. doi: 10.1016/j.exphem.2021.08.004. 
  2.  Latif AL, Newcombe A, Gilroy K, Robertson N, Li S, Stewart H, Terradas M, Rishi Delori L, McGarry L, Reid C, Clark W, Campos J, Kirschner K, Lopez J, J Sakamaki, Ryan K, Tait S, Abraham SA, Holyoake TC,. Higgins BX, Huang X, Copland M, Chevassut T, Keeshan K, Adams PD Abolition of BRD4-mediated repression of p53 target genes and stabilization of p53 is the basis of synergistic lethality of BET inhibitors and MDM2 inhibitors in AML In press Nature Communications (IF:12.1) 
  3.  Grenier-Pleau, I, Tyryshkin K, Le TD, Rudan J, Bonneil E, Thibault P, Zeng K, Lässer C, Mallinson D, Lamprou D, Hui J, Postovit LM, Chan EYW, Abraham SA. Blood Extracellular Vesicles From Healthy Individuals Regulate Haematopoietic Stem Cells as Humans Age. Aging Cell Oct 7;e13245 (IF:7.2) 
  4. Pellicano F, Park L, Hopcroft LEM, Shah MM, Jackson L, Scott MT, Clarke CJ, Sinclair A, Abraham SA, Hair A, Helgason GV, Aspinall-O'Dea M, Bhatia R, Leone G, Kranc KR, Whetton AD, Holyoake TL. Hsa-mir183/EGR1-mediated regulation of E2F1 is required for CML stem/progenitor cell survival. Blood. 2018 Feb 5. pii: blood-2017-05-783845. (IF: 17.5) 
  5. Hopcroft LEM, Abraham SA, Whetton AD, Holyoake TL. Network topology of leukaemic stem cells:  identifying and validating a dual hub. Oncoscience. 2017 Feb 24; 4(1-2):3-4. (IF:3.1) 
  6. Abraham SA and Holyoake TL. Casting a NETwork instead of shooting magic bullets. Cell Cycle. 2016      Aug 31:1-2. (IF: 3.7) 
  7. *Abraham SA, *Hopcroft      LE, Carrick E, Dunn K, Williamson AJK, Korfi K, Park LE, Scott      MT, Pellicano F, Pierce A, Copland M, Vetrie D, *Whetton AD, *Holyoake TL. Network profiling of primitive chronic myeloid leukaemia cells reveals a selective and targetable      dependency on p53 and c-Myc. Nature. 2016 Jun 8. doi: 10.1038/nature18288. (IF: 42.3) 
  8. Abraham SA. Biological analysis of human CML stem cells. Invited book chapter. Methods Mol Biol. 2016; 1465:175-85. 
  9. Sinclair A, Park L, Shah M, Calaminus S, Hopcroft LEM, Drotar M, Kinstrie R, Guitart A, Dunn K, Abraham SA, Sansom O, Michie AM, Machesky L, Kranc KR, Graham GJ, Pellicano F, Holyoake TL. CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood. 2016 Jul 21; 128(3):371-83. doi: 10.1182/blood-2015-08-661785. (IF: 17.5) 
  10. *Chen Y, *Peng C, Abraham SA (second author), Shan Y, Guo Z, Desouza N, Cheloni G, Li D, Holyoake TL, Li S. Arachidonate 15-lipoxygenase is required for chronic myeloid leukemia stem cell survival. J Clin Invest. 2014 Sep 2; 124(9):3847-62. (IF: 11.9) 
  11. Abraham SA, Hopcroft L, Bhatia R, Koschmieder S, Whetton AD and Holyoake TL. Models to Study Chronic Myeloid Leukaemia Cancer Stem Cells. Book Chapter in: Cancer Stem Cells Wiley Press 2014. 
  12. Williamson AJ, Pierce A, Jaworska E, Zhou C, Aspinall-O'Dea M, Lancashire L, Unwin RD, Abraham SA, Walker MJ, Cadecco S, Spooncer E, Holyoake TL, Whetton AD. A specific PTPRC/CD45 phosphorylation event governed by stem cell chemokine CXCL12 regulates primitive hematopoietic cell motility. Mol Cell Proteomics. 2013 Nov; 12(11):3319-29. (IF: 4.8) 
  13. Abraham SA, Holyoake TL. Redirecting traffic using the XPO1 police. Blood. 2013 Oct 24; 122(17):2926-8. (IF: 17.5) 
  14. Griaud F, Pierce A, Gonzalez Sanchez MB, Scott M, Abraham SA, Holyoake TL, Tran DD, Tamura T, Whetton AD. A pathway from leukemogenic oncogenes and stem cell chemokines to RNA processing via THOC5. Leukemia. 2013 Apr; 27(4):932-40. (IF: 8.7) 
  15. Balabanov S, Evans CA, Abraham SA, Pellicano F, Copland M, Walker MJ, Whetton AD, Holyoake TL. Quantitative proteomics analysis of BMS-214662 effects on CD34 positive      cells from chronic myeloid leukaemia patients. Proteomics. 2013 Jan; 13(1):153-68. (IF: 3.1) 
  16. Gallipoli P, Abraham SA, Holyoake TL. Hurdles toward a cure for CML: the CML stem cell. Hematol Oncol Clin North Am. 2011 Oct; 25(5):951-66. (IF: 3.1)  
  17. Viglianti BL, Ponce AM, Michelich CR, Yu D, Abraham SA, Sanders L, Yarmolenko PS,      Schroeder T, MacFall JR, Barboriak DP, Colvin OM, Bally MB, Dewhirst MW. Chemodosimetry of in vivo tumor liposomal drug concentration using MRI. Magn Reson Med. 2006 Nov; 56(5):1011-8. (IF: 3.6) 
  18. Abraham SA, Waterhouse DN, Mayer LD, Cullis PR, Madden TD, Bally MB. The Liposomal Formulation of Doxorubicin. Methods Enzymol. 2005; 391:71-97. (IF: 1.9) 
  19. Chiu GN, Abraham SA, Ickenstein LM,  Ng R, Karlsson G, Edwards K, Wasan EK, Bally MB. Encapsulation of doxorubicin into thermosensitive liposomes via complexation with the      transition metal manganese. J Control Release. 2005 May 18; 104(2):271-88. (IF: 7.6 ) 
  20. Viglianti BL, Michelich CR, Abraham SA, Colvin OM, Yarmolenko PS, Schroeder T, MacFall      JR, Bally MB, Dewhirst MW. Chemodosimetry of in-vivo tumor liposome/drug concentration using MRI. International Journal of Radiation Oncology Biology Physics 2004 September, Vol 60, 1, S225–S226.      (IF: 5.9) 
  21. Viglianti BL, Abraham SA, Michelich CR, Yarmolenko PS, MacFall JR, Bally MB, Dewhirst MW. In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: illustration of targeted delivery. Magn Reson Med. 2004 Jun; 51(6):1153-62. (IF: 3.6) 
  22. Abraham SA, Edwards K, Karlsson G, Hudon N, Mayer LD, Bally MB. An evaluation of transmembrane ion gradient-mediated encapsulation of topotecan within liposomes. J Control Release. 2004 May 18; 96(3):449-61. (IF: 7.6) 
  23. Abraham SA, McKenzie C, Masin D, Ng R, Harasym TO, Mayer LD, Bally MB. Co-encapsulation of doxorubicin and vincristine within liposomes through use of metal ion complexation method in combination with ionophore mediated induction of a pH gradient. Clin Cancer Res. 2004 Jan 15; 10(2):728-38. (IF: 10.1) 
  24. Abraham SA, Edwards K, Karlsson G, MacIntosh S, Mayer LD, McKenzie C, Bally MB. Formation of transition metal-doxorubicin complexes inside liposomes. Biochim Biophys Acta. 2002 Sep 20; 1565(1):41-54. IF: (3.4) 
  25. Dos Santos N, Mayer LD, Abraham SA, Gallagher RC, Cox KA, Tardi PG, Bally MB. Improved retention of idarubicin after intravenous injection. Biochim Biophys Acta. 2002 Apr 12; 1561(2):188-201. (IF: 3.4) 

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